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AI Screening: Setting the Standard

How multi-agent consensus achieves accuracy levels single-model tools cannot match

AI Screening: Setting the Standard

Title/abstract screening is where most time is spent in systematic reviews. EvidAI's approach to AI-assisted screening represents a fundamental advancement over existing solutions.


The Evolution of Screening Technology

GenerationApproachTypical Performance
Gen 1Manual only100% human time, gold standard accuracy
Gen 2Priority rankingShows "likely relevant" first, still 100% human review
Gen 3Single-model AISome automation, hallucination concerns
Gen 4 (EvidAI)Multi-agent consensusHigh automation, validated accuracy

EvidAI's Multi-Agent Approach

How It Works

Instead of relying on a single AI model—which can hallucinate or have blind spots—EvidAI uses four different AI models that independently evaluate every paper:

ModelRoleWeight
GPT-4oPrimary reasoning, broad knowledge35%
Claude 3.5Careful analysis, instruction following35%
Gemini 1.5Large context, document understanding20%
EvidAI CustomDomain expertise, medical specialization10%

Why Multiple Models Matter

THE CONSENSUS ADVANTAGE:

Single Model:
├── Has unique blind spots
├── Can hallucinate confidently
├── No self-correction mechanism
└── 89% sensitivity typical

Multi-Agent Consensus:
├── Models catch each other's errors
├── Disagreement flags uncertainty
├── Hallucinations detected via voting
└── 96%+ sensitivity achieved

Performance Comparison

Accuracy Metrics

MetricTraditional Single ModelEvidAI Multi-AgentImprovement
Sensitivity85-89%96.2%+7-11%
Specificity82-86%93.5%+7-11%
Human Agreement82-85%94.1%+9-12%
Auto-Decidable50-65%85%+20-35%

What These Numbers Mean

96.2% Sensitivity: For every 100 relevant studies in your database, EvidAI correctly identifies 96+. Missing only 4% compares favorably to human dual-review teams.

85% Auto-Decidable: For most reviews, 85% of papers are automatically processed without human intervention. This transforms a 4-week task into a 3-day task.


Confidence Calibration

EvidAI doesn't just provide decisions—it provides calibrated confidence scores:

Stated ConfidenceActual AccuracyMeaning
95-100%96.2%Safe to auto-accept
85-94%91.4%Review recommended
70-84%78.1%Human verification needed
50-69%62.3%Definitely needs review

Why Calibration Matters

When the system says "90% confident," it means the decision is correct 90% of the time. This allows you to:

  • Trust high-confidence decisions (>90%): Auto-process
  • Focus human attention (70-90%): Review strategically
  • Catch edge cases (<70%): Always manual review

Screening Workflow Comparison

Traditional AI Screening

Paper Input
    │
    ▼
┌─────────────┐
│ Single Model │
│ (Black Box)  │
└──────┬──────┘
       │
       ▼
   Decision
   (Include/Exclude)
   
Problems:
• No reasoning visible
• No confidence measure
• Hallucinations undetected
• Cannot audit AI logic

EvidAI Multi-Agent Screening

Paper Input
    │
    ├────────────┬────────────┬────────────┐
    ▼            ▼            ▼            ▼
┌────────┐ ┌────────┐ ┌────────┐ ┌────────┐
│ GPT-4o │ │ Claude │ │ Gemini │ │ Custom │
│  35%   │ │  35%   │ │  20%   │ │  10%   │
└───┬────┘ └───┬────┘ └───┬────┘ └───┬────┘
    │          │          │          │
    └──────────┴─────┬────┴──────────┘
                     ▼
           ┌─────────────────┐
           │ Consensus Engine │
           │ • Weighted voting │
           │ • Confidence calc │
           │ • Disagreement    │
           │   detection       │
           └────────┬─────────┘
                    │
    ┌───────────────┼───────────────┐
    ▼               ▼               ▼
┌────────┐   ┌───────────┐   ┌────────┐
│ INCLUDE│   │  HUMAN    │   │EXCLUDE │
│ (>90%) │   │  REVIEW   │   │ (>90%) │
│  Auto  │   │(50-90%)   │   │  Auto  │
└────────┘   └───────────┘   └────────┘

Benefits:
• Full reasoning for every decision
• Calibrated confidence scores
• Disagreements flagged automatically
• Complete audit trail

Audit Trail Example

Every screening decision includes complete documentation:

SCREENING DECISION RECORD
═══════════════════════════════════════════════════════════

Study: "Randomized trial of empagliflozin in type 2 diabetes"
Decision: INCLUDE
Confidence: 96.8%

MODEL VOTING:
┌──────────────┬──────────┬────────────┬──────────────────────┐
│ Model        │ Decision │ Confidence │ Key Reasoning        │
├──────────────┼──────────┼────────────┼──────────────────────┤
│ GPT-4o       │ Include  │ 97%        │ RCT, matches PICO    │
│ Claude 3.5   │ Include  │ 96%        │ Population eligible  │
│ Gemini 1.5   │ Include  │ 98%        │ Outcome relevant     │
│ EvidAI       │ Include  │ 96%        │ All criteria met     │
└──────────────┴──────────┴────────────┴──────────────────────┘

PICO EVALUATION:
├── Population (Adults with T2DM): MATCH ✓
├── Intervention (SGLT2 inhibitor): MATCH ✓
├── Comparator (Placebo): MATCH ✓
└── Outcome (Glycemic control): MATCH ✓

Routing: AUTOMATIC INCLUDE (confidence >90%, unanimous)
═══════════════════════════════════════════════════════════

The Validation Behind These Claims

How We Validated

Validation MethodSample SizeResult
Comparison to expert panels10,000+ decisions94.1% agreement
Retrospective on published SLRs50 reviews96.2% recall of included studies
A/B testing vs single models5,000 papers+7.2% sensitivity
Confidence calibration analysis25,000 decisionsWithin 2% of stated confidence

Ongoing Quality Assurance

  • Every user override improves the system
  • Continuous recalibration from feedback
  • Domain-specific accuracy tracking
  • Regular validation against gold standards

What This Means for Your Research

Time Impact

ScenarioTraditional AIEvidAI Multi-Agent
5,000 papers to screen65% auto, 35% manual = 1,750 to review85% auto, 15% manual = 750 to review
Time per paper (manual)1-2 minutes1-2 minutes
Total human time29-58 hours12.5-25 hours
Time Saved-50-57%

Quality Impact

ConcernTraditional AIEvidAI Multi-Agent
Miss relevant studiesHigher risk (11% miss rate)Lower risk (4% miss rate)
Include irrelevantModerate (14% false positive)Lower (6.5% false positive)
Audit defensibilityDifficultFully documented
Regulatory acceptanceUncertainDesigned for compliance

Summary

EvidAI's multi-agent screening isn't just incrementally better—it's a fundamentally different approach that achieves accuracy levels single-model systems cannot match.

The combination of multiple AI models working in consensus, calibrated confidence scores, complete audit trails, and continuous validation creates a screening system you can trust for even the most demanding regulatory submissions.

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