AI Screening: Setting the Standard
Title/abstract screening is where most time is spent in systematic reviews. EvidAI's approach to AI-assisted screening represents a fundamental advancement over existing solutions.
The Evolution of Screening Technology
| Generation | Approach | Typical Performance |
|---|---|---|
| Gen 1 | Manual only | 100% human time, gold standard accuracy |
| Gen 2 | Priority ranking | Shows "likely relevant" first, still 100% human review |
| Gen 3 | Single-model AI | Some automation, hallucination concerns |
| Gen 4 (EvidAI) | Multi-agent consensus | High automation, validated accuracy |
EvidAI's Multi-Agent Approach
How It Works
Instead of relying on a single AI model—which can hallucinate or have blind spots—EvidAI uses four different AI models that independently evaluate every paper:
| Model | Role | Weight |
|---|---|---|
| GPT-4o | Primary reasoning, broad knowledge | 35% |
| Claude 3.5 | Careful analysis, instruction following | 35% |
| Gemini 1.5 | Large context, document understanding | 20% |
| EvidAI Custom | Domain expertise, medical specialization | 10% |
Why Multiple Models Matter
THE CONSENSUS ADVANTAGE:
Single Model:
├── Has unique blind spots
├── Can hallucinate confidently
├── No self-correction mechanism
└── 89% sensitivity typical
Multi-Agent Consensus:
├── Models catch each other's errors
├── Disagreement flags uncertainty
├── Hallucinations detected via voting
└── 96%+ sensitivity achieved
Performance Comparison
Accuracy Metrics
| Metric | Traditional Single Model | EvidAI Multi-Agent | Improvement |
|---|---|---|---|
| Sensitivity | 85-89% | 96.2% | +7-11% |
| Specificity | 82-86% | 93.5% | +7-11% |
| Human Agreement | 82-85% | 94.1% | +9-12% |
| Auto-Decidable | 50-65% | 85% | +20-35% |
What These Numbers Mean
96.2% Sensitivity: For every 100 relevant studies in your database, EvidAI correctly identifies 96+. Missing only 4% compares favorably to human dual-review teams.
85% Auto-Decidable: For most reviews, 85% of papers are automatically processed without human intervention. This transforms a 4-week task into a 3-day task.
Confidence Calibration
EvidAI doesn't just provide decisions—it provides calibrated confidence scores:
| Stated Confidence | Actual Accuracy | Meaning |
|---|---|---|
| 95-100% | 96.2% | Safe to auto-accept |
| 85-94% | 91.4% | Review recommended |
| 70-84% | 78.1% | Human verification needed |
| 50-69% | 62.3% | Definitely needs review |
Why Calibration Matters
When the system says "90% confident," it means the decision is correct 90% of the time. This allows you to:
- Trust high-confidence decisions (>90%): Auto-process
- Focus human attention (70-90%): Review strategically
- Catch edge cases (<70%): Always manual review
Screening Workflow Comparison
Traditional AI Screening
Paper Input
│
▼
┌─────────────┐
│ Single Model │
│ (Black Box) │
└──────┬──────┘
│
▼
Decision
(Include/Exclude)
Problems:
• No reasoning visible
• No confidence measure
• Hallucinations undetected
• Cannot audit AI logic
EvidAI Multi-Agent Screening
Paper Input
│
├────────────┬────────────┬────────────┐
▼ ▼ ▼ ▼
┌────────┐ ┌────────┐ ┌────────┐ ┌────────┐
│ GPT-4o │ │ Claude │ │ Gemini │ │ Custom │
│ 35% │ │ 35% │ │ 20% │ │ 10% │
└───┬────┘ └───┬────┘ └───┬────┘ └───┬────┘
│ │ │ │
└──────────┴─────┬────┴──────────┘
▼
┌─────────────────┐
│ Consensus Engine │
│ • Weighted voting │
│ • Confidence calc │
│ • Disagreement │
│ detection │
└────────┬─────────┘
│
┌───────────────┼───────────────┐
▼ ▼ ▼
┌────────┐ ┌───────────┐ ┌────────┐
│ INCLUDE│ │ HUMAN │ │EXCLUDE │
│ (>90%) │ │ REVIEW │ │ (>90%) │
│ Auto │ │(50-90%) │ │ Auto │
└────────┘ └───────────┘ └────────┘
Benefits:
• Full reasoning for every decision
• Calibrated confidence scores
• Disagreements flagged automatically
• Complete audit trail
Audit Trail Example
Every screening decision includes complete documentation:
SCREENING DECISION RECORD
═══════════════════════════════════════════════════════════
Study: "Randomized trial of empagliflozin in type 2 diabetes"
Decision: INCLUDE
Confidence: 96.8%
MODEL VOTING:
┌──────────────┬──────────┬────────────┬──────────────────────┐
│ Model │ Decision │ Confidence │ Key Reasoning │
├──────────────┼──────────┼────────────┼──────────────────────┤
│ GPT-4o │ Include │ 97% │ RCT, matches PICO │
│ Claude 3.5 │ Include │ 96% │ Population eligible │
│ Gemini 1.5 │ Include │ 98% │ Outcome relevant │
│ EvidAI │ Include │ 96% │ All criteria met │
└──────────────┴──────────┴────────────┴──────────────────────┘
PICO EVALUATION:
├── Population (Adults with T2DM): MATCH ✓
├── Intervention (SGLT2 inhibitor): MATCH ✓
├── Comparator (Placebo): MATCH ✓
└── Outcome (Glycemic control): MATCH ✓
Routing: AUTOMATIC INCLUDE (confidence >90%, unanimous)
═══════════════════════════════════════════════════════════
The Validation Behind These Claims
How We Validated
| Validation Method | Sample Size | Result |
|---|---|---|
| Comparison to expert panels | 10,000+ decisions | 94.1% agreement |
| Retrospective on published SLRs | 50 reviews | 96.2% recall of included studies |
| A/B testing vs single models | 5,000 papers | +7.2% sensitivity |
| Confidence calibration analysis | 25,000 decisions | Within 2% of stated confidence |
Ongoing Quality Assurance
- Every user override improves the system
- Continuous recalibration from feedback
- Domain-specific accuracy tracking
- Regular validation against gold standards
What This Means for Your Research
Time Impact
| Scenario | Traditional AI | EvidAI Multi-Agent |
|---|---|---|
| 5,000 papers to screen | 65% auto, 35% manual = 1,750 to review | 85% auto, 15% manual = 750 to review |
| Time per paper (manual) | 1-2 minutes | 1-2 minutes |
| Total human time | 29-58 hours | 12.5-25 hours |
| Time Saved | - | 50-57% |
Quality Impact
| Concern | Traditional AI | EvidAI Multi-Agent |
|---|---|---|
| Miss relevant studies | Higher risk (11% miss rate) | Lower risk (4% miss rate) |
| Include irrelevant | Moderate (14% false positive) | Lower (6.5% false positive) |
| Audit defensibility | Difficult | Fully documented |
| Regulatory acceptance | Uncertain | Designed for compliance |
Summary
EvidAI's multi-agent screening isn't just incrementally better—it's a fundamentally different approach that achieves accuracy levels single-model systems cannot match.
The combination of multiple AI models working in consensus, calibrated confidence scores, complete audit trails, and continuous validation creates a screening system you can trust for even the most demanding regulatory submissions.